:root{
  --ink:#14202b; --ink-soft:#3a4b58; --muted:#6b7c88;
  --teal:#0f766e; --teal-deep:#0b544e; --teal-soft:#e6f4f1;
  --amber:#c2703d;
  --bg:#f7f5f1; --card:#ffffff; --line:#e5e0d8;
  --maxw:1080px;
}
*{box-sizing:border-box;margin:0;padding:0}
html{scroll-behavior:smooth}
body{font-family:'Inter',system-ui,sans-serif;color:var(--ink);background:var(--bg);line-height:1.65;-webkit-font-smoothing:antialiased}
h1,h2,h3,h4{font-family:'Fraunces',Georgia,serif;line-height:1.15;font-weight:600;color:var(--ink)}
a{color:var(--teal);text-decoration:none}
a:hover{text-decoration:underline}
.wrap{max-width:var(--maxw);margin:0 auto;padding:0 24px}
.eyebrow{font-family:'Inter';font-size:.8rem;font-weight:600;letter-spacing:.12em;text-transform:uppercase;color:var(--teal)}
header.site{position:sticky;top:0;z-index:50;background:rgba(247,245,241,.85);backdrop-filter:blur(10px);border-bottom:1px solid var(--line)}
.nav{display:flex;align-items:center;justify-content:space-between;height:68px}
.brand{display:flex;align-items:center;gap:12px;font-family:'Fraunces';font-weight:600;font-size:1.15rem;color:var(--ink)}
.brand:hover{text-decoration:none}
.nav-links{display:flex;gap:28px;align-items:center}
.nav-links a{color:var(--ink-soft);font-size:.92rem;font-weight:500}
.nav-cta{background:var(--teal);color:#fff !important;padding:9px 18px;border-radius:999px;font-size:.9rem}
.nav-cta:hover{background:var(--teal-deep);text-decoration:none}
@media(max-width:760px){.nav-links a:not(.nav-cta):not(.nav-patients){display:none}.nav-links{gap:10px}.nav-links a{white-space:nowrap;font-size:.85rem}.nav-cta{padding:8px 14px}.brand{font-size:1rem;gap:8px}.brand svg{width:26px;height:26px}}
@media(max-width:420px){.brand-t{display:none}}
.hero{padding:90px 0 70px;background:radial-gradient(1200px 500px at 80% -10%, var(--teal-soft), transparent 60%),radial-gradient(900px 400px at 0% 10%, #fbeee4, transparent 55%);}
.hero .eyebrow{margin-bottom:18px}
.hero h1{font-size:clamp(2.2rem,5vw,3.6rem);letter-spacing:-.01em;max-width:15ch}
.hero .lede{font-size:1.35rem;color:var(--ink-soft);margin:22px 0 8px;max-width:34ch;font-family:'Fraunces';font-weight:400}
.hero p.body{font-size:1.08rem;color:var(--ink-soft);max-width:60ch;margin-top:20px}
.hero-actions{display:flex;gap:14px;flex-wrap:wrap;margin-top:32px}
.hero-diag{margin-top:22px;font-size:1.02rem;color:var(--ink-soft)}
.hero-diag a{font-weight:600}
.hero-signup{margin-top:38px;max-width:520px}
.hero-signup .signup-label{font-family:'Inter';font-size:.8rem;font-weight:600;letter-spacing:.12em;text-transform:uppercase;color:var(--teal);margin-bottom:6px}
.hero-signup .signup-note{font-size:.95rem;color:var(--muted);margin-bottom:14px;max-width:46ch}
.hero-signup iframe{max-width:100%!important;border:0;display:block}
@media(max-width:640px){.hero-signup{margin-top:30px}}
.btn{display:inline-flex;align-items:center;gap:8px;padding:13px 24px;border-radius:999px;font-weight:600;font-size:1rem;transition:.2s}
.btn-primary{background:var(--teal);color:#fff}
.btn-primary:hover{background:var(--teal-deep);text-decoration:none;transform:translateY(-1px)}
.btn-ghost{background:#fff;color:var(--ink);border:1px solid var(--line)}
.btn-ghost:hover{border-color:var(--teal);color:var(--teal);text-decoration:none}
.stats{display:grid;grid-template-columns:repeat(3,1fr);gap:18px;margin-top:56px}
.stat{background:var(--card);border:1px solid var(--line);border-radius:16px;padding:24px}
.stat .n{font-family:'Fraunces';font-size:1.5rem;font-weight:600;color:var(--teal-deep)}
.stat .l{font-weight:600;margin:6px 0 4px}
.stat .d{font-size:.92rem;color:var(--muted)}
@media(max-width:760px){.stats{grid-template-columns:1fr}}
section{padding:74px 0}
.section-head{max-width:60ch;margin-bottom:36px}
.section-head h2{font-size:clamp(1.7rem,3.5vw,2.5rem);letter-spacing:-.01em;margin-top:10px}
.section-head p{color:var(--ink-soft);font-size:1.1rem;margin-top:16px}
.prose p{color:var(--ink-soft);max-width:68ch;margin-bottom:18px;font-size:1.05rem}
.alt{background:linear-gradient(180deg,#fff,#fbfaf7);border-top:1px solid var(--line);border-bottom:1px solid var(--line)}
.case{background:var(--card);border:1px solid var(--line);border-radius:20px;padding:34px;box-shadow:0 1px 2px rgba(20,32,43,.04)}
.case-tag{display:inline-block;background:var(--ink);color:#fff;font-size:.78rem;font-weight:600;letter-spacing:.08em;padding:5px 12px;border-radius:6px;margin-bottom:14px}
.case h3{font-size:1.5rem}
.case .sub{color:var(--muted);font-size:.98rem;margin:6px 0 22px;font-family:'Inter'}
.genes{list-style:none;display:grid;gap:12px}
.genes li{padding:14px 16px;background:#faf9f6;border:1px solid var(--line);border-radius:12px;font-size:.98rem;color:var(--ink-soft)}
.genes li b{color:var(--ink);font-family:'Inter'}
.tag-disc{color:#b23c3c;font-weight:600;font-size:.82rem;background:#fbeaea;padding:2px 8px;border-radius:5px;margin-left:4px}
.tag-exp{color:var(--teal-deep);font-weight:600;font-size:.82rem;background:var(--teal-soft);padding:2px 8px;border-radius:5px;margin-left:4px}
.note{font-size:.92rem;color:var(--muted);margin-top:20px;padding-top:18px;border-top:1px dashed var(--line)}
.steps{display:grid;grid-template-columns:repeat(2,1fr);gap:20px}
@media(max-width:760px){.steps{grid-template-columns:1fr}}
.step{background:var(--card);border:1px solid var(--line);border-radius:16px;padding:24px;position:relative}
.step .num{width:34px;height:34px;border-radius:9px;background:var(--teal-soft);color:var(--teal-deep);display:flex;align-items:center;justify-content:center;font-family:'Fraunces';font-weight:700;margin-bottom:14px}
.step h4{font-size:1.12rem;font-family:'Inter';font-weight:700;margin-bottom:6px}
.step p{color:var(--ink-soft);font-size:.96rem}
.guides{display:grid;grid-template-columns:repeat(3,1fr);gap:18px}
@media(max-width:900px){.guides{grid-template-columns:repeat(2,1fr)}}
@media(max-width:600px){.guides{grid-template-columns:1fr}}
a.guide{display:block;background:var(--card);border:1px solid var(--line);border-radius:16px;padding:22px 22px 20px;color:var(--ink);transition:.2s}
a.guide:hover{text-decoration:none;border-color:var(--teal);transform:translateY(-2px);box-shadow:0 6px 18px rgba(20,32,43,.06)}
a.guide .gk{font-family:'Inter';font-size:.76rem;font-weight:700;letter-spacing:.1em;text-transform:uppercase;color:var(--teal);margin-bottom:8px}
a.guide h4{font-family:'Fraunces';font-size:1.18rem;margin-bottom:8px}
a.guide p{color:var(--ink-soft);font-size:.95rem}
a.guide .go{display:block;margin-top:12px;font-weight:600;color:var(--teal);font-size:.92rem}
.asks{display:grid;grid-template-columns:1fr 1fr;gap:22px;margin-top:10px}
@media(max-width:760px){.asks{grid-template-columns:1fr}}
.ask{background:var(--card);border:1px solid var(--line);border-radius:18px;padding:30px;display:flex;flex-direction:column}
.ask h3{font-size:1.3rem;margin-bottom:12px}
.ask p{color:var(--ink-soft);font-size:1rem;margin-bottom:14px}
.ask .spacer{flex-grow:1}
.ask .btn{align-self:flex-start;margin-top:10px}
.res-group{margin-bottom:34px}
.res-group h4{font-family:'Inter';font-weight:700;font-size:.85rem;letter-spacing:.1em;text-transform:uppercase;color:var(--teal);margin-bottom:16px;padding-bottom:8px;border-bottom:1px solid var(--line)}
.res-list{display:grid;gap:14px}
.res{background:var(--card);border:1px solid var(--line);border-radius:12px;padding:16px 18px}
.res .rt{font-weight:600;color:var(--ink)}
.res .rd{color:var(--ink-soft);font-size:.94rem;margin-top:5px}
.callout{background:var(--teal);color:#fff;border-radius:20px;padding:40px;text-align:center}
.callout p{font-size:1.2rem;font-family:'Fraunces';max-width:50ch;margin:0 auto}
.callout a{color:#fff;text-decoration:underline}
.legal{font-size:.92rem;color:var(--muted)}
.legal h3{font-family:'Inter';font-weight:700;font-size:1rem;color:var(--ink);margin:20px 0 8px}
.legal p{margin-bottom:12px;max-width:70ch}
.legal b{color:var(--ink-soft)}
footer.site{background:var(--ink);color:#c3ced6;padding:56px 0 34px;margin-top:20px}
footer.site .brand{color:#fff;margin-bottom:16px}
footer.site a{color:#8fd4cb}
.foot-grid{display:grid;grid-template-columns:2fr 1fr 1fr;gap:40px}
@media(max-width:760px){.foot-grid{grid-template-columns:1fr}}
.foot-note{font-size:.86rem;color:#7d8b95;max-width:50ch}
.foot-bottom{border-top:1px solid #2a3a46;margin-top:34px;padding-top:20px;font-size:.82rem;color:#6b7b86;display:flex;justify-content:space-between;flex-wrap:wrap;gap:10px}
.disclaimer{background:#fdf6ee;border:1px solid #f0e2d0;border-radius:14px;padding:20px 24px;color:#6b5a45;font-size:.96rem;margin-top:30px}

/* ---------- Article / guide pages ---------- */
.crumbs{font-size:.86rem;color:var(--muted);margin:26px 0 0}
.crumbs a{color:var(--muted)}
.crumbs span{margin:0 8px;color:#b9c2c8}
.article-head{padding:34px 0 26px;max-width:72ch}
.article-head h1{font-size:clamp(2rem,4.2vw,3rem);letter-spacing:-.01em;margin-top:12px}
.article-head .lede{font-size:1.2rem;color:var(--ink-soft);margin-top:18px;font-family:'Fraunces';font-weight:400;max-width:60ch}
.article-meta{font-size:.86rem;color:var(--muted);margin-top:16px}
.article-grid{display:grid;grid-template-columns:minmax(0,1fr) 260px;gap:48px;align-items:start;padding-bottom:70px}
@media(max-width:900px){.article-grid{grid-template-columns:1fr}}
.article{max-width:72ch}
.article h2{font-size:clamp(1.45rem,2.6vw,1.9rem);margin:44px 0 14px;letter-spacing:-.01em;scroll-margin-top:90px}
.article h3{font-size:1.18rem;margin:28px 0 10px;font-family:'Inter';font-weight:700}
.article p{color:var(--ink-soft);font-size:1.05rem;margin-bottom:16px}
.article ul,.article ol{color:var(--ink-soft);font-size:1.03rem;margin:0 0 18px 22px}
.article li{margin-bottom:8px}
.article li::marker{color:var(--teal)}
.article b,.article strong{color:var(--ink)}
.article table{width:100%;border-collapse:collapse;font-size:.95rem;margin:10px 0 22px;background:var(--card);border:1px solid var(--line);border-radius:12px;overflow:hidden}
.article th,.article td{padding:10px 12px;text-align:left;border-bottom:1px solid var(--line);vertical-align:top;color:var(--ink-soft)}
.article th{font-family:'Inter';font-size:.8rem;letter-spacing:.06em;text-transform:uppercase;color:var(--teal);background:#faf9f6}
.article tr:last-child td{border-bottom:0}
.article sup a{font-size:.72em;font-weight:600;color:var(--teal);text-decoration:none;margin-left:1px}
.keyfacts{background:var(--card);border:1px solid var(--line);border-left:4px solid var(--teal);border-radius:14px;padding:20px 22px;margin:22px 0 28px}
.keyfacts h3{margin:0 0 10px;font-size:.82rem;letter-spacing:.1em;text-transform:uppercase;color:var(--teal);font-family:'Inter'}
.keyfacts ul{margin:0 0 0 20px;font-size:1rem}
.keyfacts li{margin-bottom:6px}
.aside{position:sticky;top:90px}
.toc{background:var(--card);border:1px solid var(--line);border-radius:14px;padding:18px 20px;margin-bottom:18px}
.toc h4{font-family:'Inter';font-size:.78rem;letter-spacing:.1em;text-transform:uppercase;color:var(--teal);margin-bottom:10px}
.toc ol{list-style:none;margin:0;padding:0}
.toc li{margin:0 0 8px;font-size:.93rem;line-height:1.4}
.toc a{color:var(--ink-soft)}
.aside-cta{background:var(--teal);color:#fff;border-radius:14px;padding:20px 22px}
.aside-cta h4{color:#fff;font-family:'Fraunces';font-size:1.15rem;margin-bottom:8px}
.aside-cta p{font-size:.93rem;color:#d9efeb;margin-bottom:14px}
.aside-cta .btn{background:#fff;color:var(--teal-deep);padding:10px 18px;font-size:.92rem}
.aside-cta .btn:hover{background:#eef7f5;text-decoration:none}
.aside-nav{margin-top:18px;font-size:.9rem}
.aside-nav h4{font-family:'Inter';font-size:.78rem;letter-spacing:.1em;text-transform:uppercase;color:var(--teal);margin-bottom:10px}
.aside-nav a{display:block;color:var(--ink-soft);padding:5px 0;border-bottom:1px dashed var(--line)}
.aside-nav a.current{color:var(--teal);font-weight:600}
.sources{margin-top:46px;padding-top:22px;border-top:1px solid var(--line)}
.sources h2{font-size:1.2rem;margin:0 0 12px}
.sources ol{font-size:.9rem;color:var(--muted);margin-left:20px}
.sources li{margin-bottom:8px;word-break:break-word}
.disclaimer.small{font-size:.9rem;margin-top:26px}
.faq details{background:var(--card);border:1px solid var(--line);border-radius:12px;padding:14px 18px;margin-bottom:10px}
.faq summary{cursor:pointer;font-weight:600;color:var(--ink);font-family:'Inter'}
.faq details p{margin:10px 0 0;font-size:1rem}
.checklist{list-style:none;margin:0 0 20px}
.checklist li{position:relative;padding:12px 14px 12px 44px;background:var(--card);border:1px solid var(--line);border-radius:12px;margin-bottom:8px;color:var(--ink-soft)}
.checklist li::before{content:"";position:absolute;left:14px;top:14px;width:18px;height:18px;border:2px solid var(--teal);border-radius:5px;background:#fff}
.next-steps{display:grid;grid-template-columns:1fr 1fr;gap:16px;margin-top:30px}
@media(max-width:700px){.next-steps{grid-template-columns:1fr}}
.hub-intro{max-width:70ch}
.hub-intro p{font-size:1.1rem;color:var(--ink-soft);margin-bottom:16px}
.lang-note{font-size:.9rem;color:var(--muted);margin-top:10px}
/* ---------- Forms ---------- */
.form{background:var(--card);border:1px solid var(--line);border-radius:18px;padding:30px;max-width:720px}
.form .row{margin-bottom:18px}
.form label{display:block;font-weight:600;font-size:.95rem;margin-bottom:6px;color:var(--ink)}
.form .hint{font-size:.86rem;color:var(--muted);margin-top:4px}
.form input[type=text],.form input[type=email],.form select,.form textarea{width:100%;padding:12px 14px;border:1px solid var(--line);border-radius:10px;font:inherit;font-size:1rem;background:#fff;color:var(--ink)}
.form textarea{min-height:170px;resize:vertical}
.form input:focus,.form select:focus,.form textarea:focus{outline:2px solid var(--teal-soft);border-color:var(--teal)}
.form .check{display:flex;gap:10px;align-items:flex-start;font-size:.95rem;color:var(--ink-soft)}
.form .check input{margin-top:4px;width:18px;height:18px;flex:0 0 auto}
.form .hp{position:absolute;left:-9999px;top:-9999px;height:0;overflow:hidden}
.form button{border:0;cursor:pointer;font-family:inherit}
.alert{border-radius:12px;padding:16px 18px;margin-bottom:22px;font-size:1rem}
.alert.ok{background:var(--teal-soft);color:var(--teal-deep);border:1px solid #bfe3dc}
.alert.err{background:#fbeaea;color:#8a2a2a;border:1px solid #f1c9c9}
.form-grid{display:grid;grid-template-columns:1fr 1fr;gap:16px}
@media(max-width:640px){.form-grid{grid-template-columns:1fr}}
@media print{header.site,footer.site,.aside,.next-steps,.crumbs{display:none!important}body{background:#fff}.article{max-width:none}.checklist li::before{border-color:#000}}